Our research has two, closely related goals. One goal is to better understand how genes and neural networks in the brain and spinal cord control movement. More recently, we’ve establish a second goal, which is provide new insight into epilepsy and develop new therapeutics to treat these disorders.

To pursue both of our research goals we use zebrafish. Developing zebrafish have several features that make it a great model system. The embryos and larvae develop quickly, exhibit strong motor behavior, are transparent so their brains can be easily observed, and we can use the power of zebrafish genetics to investigate how genes regulate nervous system function. These features allow us to take an integrated genetic, microscopic imaging, and behavioral approach to study the neural networks that control movement. Since many genes and aspects of brain function are conserved among vertebrates, developing zebrafish offer many advantages to model genetic epilepsies, investigate how neural networks are disrupted to cause seizures, and establish a high-throughput platform to identify new therapeutic compounds.

The Latest:

May 2020-  COVID-19 brought a tough semester, but Chinemerem defends his undergraduate thesis and graduates. Chinemerem, we’re so proud of you! Good luck working as a research coordinator at Massachusetts General Hospital while applying to med school. 

December 2019 – Gabi defends her undergraduate thesis and graduates. Gabi, you’re a rockstar! Good luck working as a lab technician at Brigham and Women’s Hospital while applying to med schools. 

November  2019 – Gregory and Wayne present their work at the Zebrafish Neural Circuits & Behavior conference at Cold Spring Harbor, NY. Great job! We look forward to each of them publishing some of their work soon!